Dennis M. Lox M.D. on A New Look at Regenerative Medicine and Knee Pain

Anterior cruciate ligaments (ACL)Knee pain is a common topic in sports medicine, orthopedics and arthritis clinics.
The knee is frequently injured in sports and is a common problem of the aging population with knee osteoarthritis. Knee pain may also be a presentation of rheumatoid arthritis or arthritis variants. Regenerative Medicine is fast becoming a popular alternative treatment strategy for knee disorders.

Having a basic appreciation for the anatomy and function of a knee joint is helpful to understand how Regenerative Medicine may be helpful to heal knee problems. The knee is both a simplistic hinge joint, as well as a sophisticated shock absorber, and an amazingly sophisticated system to aid in human sports endeavors. The knee is composed of two connecting bones the upper femur and lower tibia. These bones are covered in smooth cartilage, and overlying the tibia is the medial and lateral meniscus.

The cross-linked anterior cruciate ligaments (ACL), and the posterior cruciate (PCL) Prevent the tibia and femur from sliding out of position forward or backward. The sides of the tibia and femur are connected by the medial and lateral collateral ligaments. Two other bones the kneecap or patella and the small lower leg bone the fibula are often associated with knee problems. Lastly, the overlying muscles that allow knee flexion (bending) the large quadriceps,  and knee extension (hamstrings) are integral parts of the knee mechanism.

Injuries may occur any of these previously mentioned sites. These are also sites of the major knee surgeries, such as ACL repair, meniscal resection, and total knee replacement. Regenerative Medicine has also become a common treatment option after, or to prevent these surgeries. Regenerative Medicine includes Tissue Engineering, Stem Cell Science, Biologics and Platelet Rich Plasma (PRP). Dr. Lox is a leading expert in the field of Regenerative Medicine, has treated patients from all walks of life, sports, and ages. This experience helps set Dr. Lox apart from those new to the field, lacking this expertise. Each patient deserves the attention to their unique problem to aid in their successful outcome.

Do you have a question you would like to ask Dr. Lox about Stem Cell Therapy and if it will work for you?

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Dr. Lox Lectures at Perinatal Regenerative Medicine Meeting with Dr. Anthony Atala

Dr. Dennis Lox was an invited speaker at the International Perinatal Society Meeting in Teaneck, New Jersey May 2017. One of the Keynote speakers was world-renowned Stem Cell expert Dr. Anthony Atala of Wake Forest Regenerative Medicine Institute. Dr. Atala spoke about his vast experience in the field of Regenerative Medicine Stem cell and developments in the field of 3-D Bioprinting, Tissue Engineering, and Stem Cell Science.

Dr. Lox spoke on Sports and Regenerative Medicine. The world recognized Andrews Orthopedic Institute, was represented by Dr. Adam Anz who spoke on the Regenerative Medicine developments at The Andrews Orthopedic Institute.

This meeting brought forth experts in the Perinatal stem cell field. Their work has been instrumental to new Regenerative Medicine concepts and advances. There were lengthy discussions on the differences of a medical device approved therapies and approved drug therapies. The public is often confused by conflicting and misinformation brought forth by groups with conflicts of interest. Dr. Lox has been a pioneer in Regenerative Medicine, and stem cell science in patients with sports and musculoskeletal injuries, and therefore is well versed in all aspects of human cell stem cell science. Dr. Atala edited a textbook on Perinatal Stem Cells, as well as textbooks on Regenerative Medicine. Dr. Atala has been featured on 60 Minutes for his work in the field of Regenerative Medicine Stem Cell Science and Tissue Engineering and is considered one of the worlds foremost experts in the field.

Do you have a question you would like to ask Dr. Lox about Stem Cell Therapy and if it will work for you?


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A Patient from New York with AVN (Hip) consults Dr. Lox

A patient from New York diagnosed with avascular necrosis (AVN hip), flew to see Dennis M. Lox M.D an expert in Sports and Regenerative. Dr. Lox has special expertise in the area of avascular necrosis. AVN sometimes called osteonecrosis, occurs when the blood flow to a region of bone is impaired. This impaired blood flow leads to ischemia of the bone or necrosis. Literally, the bone cells die. This is why AVN is also sometimes referred to as ischemic necrosis. All the names are the same problem, just different monikers for the same disorder.

Regenerative Medicine has become an increasingly popular alternative strategy for the treatment of AVN (hip). The gravest concern with the diagnosis of avascular necrosis is the necrotic region of bone may collapse, leading to rapid joint destruction. Often a joint replacement surgery is then recommended. The hip is the most commonly affected joint with AVN. Trauma is by far the leading cause of AVN. Sometimes no known cause is identified and this is referred to as idiopathic or unknown. The hip can frequently be affected on both sides, or present atypical in a hip and a knee. Early diagnosis and treatment with an expert skilled in treating AVN are important.

AVN If diagnosed early may preserve a patients options with Regenerative Medicine. Too often patients are told to wait and see. Meaning if the AVN gets worse, hip replacement surgery is the next step. This is not appealing to most patients, especially athletes. This has lead to the expansion of patients seeking Regenerative Medicine options as an alternative strategy to just waiting and see what happens. This type of proactive approach is the hallmark of Regenerative Medicine. Helping the body to heal itself, is not only appealing it is proactive.

Repair and regenerate are the cornerstones of Regenerative Medicine and Tissue Engineering. The ability to repair the damage associated with avascular necrosis has helped athletes to return to their chosen sport. Some legendary athletes like Bo Jackson developed hip AVN, which ended his football career. Dr. Lox has successfully helped teen athletes, who were told they needed joint fusion or joint replacement. Dr. Lox assisted them to go back to their sport and get collegiate sports scholarships. Dr. Lox has incorporated Regenerative Medicine strategies successfully not only for athletes, but patients who wish to just have a normal lifestyle, and avoid hip replacement surgery. All are worthwhile goals.

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Black Belt Martial Artist with Knee Arthritis Consults Dr. Lox For Regenerative Therapy

A Black belt martial artist with knee arthritis, consulted Dennis M. Lox M.D. for knee arthritis. Martial artists frequently train in multiple sports. This one who consulted Dr. Lox, was a football player, and weightlifter/ bodybuilder as well. Dr. Lox is a world recognized Sports and Regenerative Medicine expert who treats patients in the Tampa Bay, Florida and in Beverly Hills, California.
A martial artist with knee pain and arthritis will have difficulty with kicking and jumping. They frequently train on heavy bags with kicking moves that place great stress on the knee.
If they also are weightlifting, squats, leg press, leg extensions are very hard on an already compromised knee joint. All factors must be considered when evaluating and treating an athlete with Regenerative Therapy. Dr. Lox will tailor a treatment plan for each patient and athlete. Dr. Lox has treated many styles of martial artists. He also has treated professional bodybuilders, including the highest professional level the Mr. Olympia. A knowledge of the athlete’s sports, their training regimens, and the joints and muscles involved is an important aspect of a successful Sports and Regenerative Medicine treatment plan.
The knee joint may develop arthritis as the result of years of athletic training. It may be compounded by prior sports injury to the knee, and often accelerated by the combination of knee injury followed by knee surgery. It is very common to see multi-sport athletes who may have injured their knee playing football in high school or college then become a martial artist for decades and later after mastering their discipline attaining a black belt or beyond, develop knee pain. These athletes are often surprised when told their knee has arthritis. Most people think arthritis is a problem confined to the elderly. This is not the case. Arthritis or more accurately known as knee osteoarthritis can develop at a much younger age especially with trauma, and sports injury. A sports history buff can only look at the career of NFL professional football quarterback Joe Namath to see this. Namath had his first knee surgery in college, followed by multiple more while playing in the NFL. He won the 1969 Super Bowl and earned immense fame, yet his career was significantly shortened by his injuries and knee surgeries. Joe Namath ended up having both knees replaced after he retired.
This is exactly why Martial Artists and all types of athletes consult Dr. Lox for Sports and Regenerative Medicine alternative options. Most athletes desire to continue their sports. Martial Artists devout years to developing their mind and body. Having a major joint like their knee fail them in their sport is disheartening say the least. All patients are different they come in many sizes and shapes. Knee arthritis may be mild or more advanced. So this multitude of factors are used by Dr. Lox to determine the best Regenerative Medicine strategy for each patient. With this approach the best results are achieved, and a greater likelihood of return to sports performance is obtained.

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Your Shoulder and Regenerative Medicine

Your shoulder is a frequent source of pain for athlete and non-athletes alike. The shoulder is used all day for all sort of tasks we take for granted. As we age it not uncommonly develops arthritis. It also is frequently injured in sports. Shoulder problems have ended many baseball pitchers career. Regenerative Medicine is now becoming a more popular option for not just athletes with shoulder pain, but people looking for just a better quality of life.

The shoulder is a ball and socket joint, therefore it is capable of moving in many directions. This ability to have great mobility and motion, also allows it be inured at these extreme of motion. Imagine a baseball pitcher hurling a fastball at over 90 mph. His arm goes through a tremendous arc of motion. The velocity of the pitch also places great strain on the entire shoulder mechanism. No wonder rotator cuff tears and glenoid labral tears in pitchers can be career ending even with surgery.

Now let’s look at the average gym weightlifter/ bodybuilder. Shoulder presses, bench presses, bar dips, incline bench press, heavy dumbbell presses and flyes. All rough on the shoulder, and they do it for years.

When glenoid tears, rotator cuff tears, impingement syndrome, down sloping acromiums, and gleno-numeral arthritis occur. Regenerative Medicine may be the answer. First of all, a consultation with an experienced Regenerative Medicine specialist is necessary. Dennis M. Lox M.D. Is an expert in Sports and Regenerative Medicine. Having treated nearly every type of athlete with shoulder including professional athletes, Dr. Lox has the experience to evaluate your condition, and recommend Regenerative Medicine treatment options. Dr. Lox has also treated athletes with shoulder avascular necrosis (AVN). Avascular necrosis or AVN occurs when a portion of the shoulder arm bone (the humerus) loses blood supply, and a portion of the bone in the shoulder dies. A difficult situation for an athlete and a non-athlete. Dr. Lox has the experience to help you better understand your shoulder, what is wrong, and what Regenerative Medicine options may be available to you.

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Avascular Necrosis of the Hip or Femur

Avascular Necrosis (AVN) is a frequent cause of concern for patients. When they are told they may have AVN, they are often surprised and confused by the conflicting information they receive. This may lead them on a search for alternative strategies such as Regenerative Medicine. AVN arises when the blood supply to a region of bone becomes compromised, leading to bone cell death or necrosis.

Avascular necrosis occurs most frequently from trauma. The hip is the most frequently encountered joint with AVN. A frustrating concern for patients is when know known cause or risk factor is readily identified. This leads to the term of idiopathic or unknown cause of the avascular necrosis. Other frequent causes or risk factors include excessive corticosteroids (cortisone), excessive alcohol use, Rheumatologic diseases, radiation and chemotherapy, and sickle cell disease.

The hip can develop AVN on both sides or may even be seen in one hip and a knee. Unusual presentations do develop, this is an important reason to seek the consultation of an expert such as Dr. Dennis Lox, who has treated AVN, and is familiar with treatment options including Regenerative Medicine. A frequent recommendation for hip AVN may be a hip replacement. This is why early diagnosis and consultation with an experienced physician in the treatment of hip and other forms of avascular necrosis is paramount. The key issue is the region of dead or necrotic bone may collapse, leading to a rapid destruction of the hip joint. Once the hip joint is destroyed options are limited. This is again why prompt diagnosis is important.

Athletes with hip AVN are often told they may need a hip replacement surgery. This is terrifying not just a patient, but to the athlete, as this means often it is an end to their sports career. This has led many to explore alternative treatment options such as Regenerative Medicine. The ability to help you he body heal itself without surgery is a cornerstone of Regenerative Medicine. Tissue Engineering and Stem cell research are key aspects of Regenerative Medicine. This is very appealing to athletes. Not only may Regenerative Medicine save their sports career, it may help them lead more productive lives, play sports longer, and alter the progressive nature of degenerative arthritis.
All things most active people, as well as athletes desire.

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Dr. Lox on Bodybuilding and Knee Arthritis: A Regenerative Medicine Approach

Dr. Lox on Bodybuilding and Knee Arthritis: A Regenerative Medicine Approach

Knee pain and bodybuilding are common. Dennis M. Lox M.D. has treated some of the world’s most acclaimed bodybuilders, including the highest level Mr. Olympia with Regenerative Medicine. Knee pain of a variety of disorders may develop from bodybuilding. Acute injuries from ruptured tendons, meniscal and ACL tears, knee cap (patella) pain, and tendinitis all are common. Over time, wear and tear occurs from the excessive loads of heavy weights being lifted repetitively. This may result in an early development of knee arthritis or osteoarthritis. Athletes are notorious for ignoring pain, taking anti-inflammatory medications, ice and even pain pills to keep training and lifting weights. The effects of heavy squats, leg presses, hack squats, lunges, and leg extensions over time, exerts a heavy toll on the knee of the bodybuilder.

Often athletes may not identify themselves as a pure bodybuilder. Some feel only bodybuilding competition athletes are really bodybuilders. This is inaccurate.

Bodybuilding is basically training the body through weights and exercise to be stronger, more defined and toned. This is really most individuals who regularly go to any gym. Often the recreational “bodybuilder” or fitness buff, has the least information on real science of how muscles work and nutrition. This is a natural setup for overuse training, improper training, and excessive knee wear and tear= arthritis development. Those who train and are overweight are unaware that their goal of getting in shape if done improper, may only propel the wear and tear effect of degenerative knee arthritis. For every ten pounds of excessive weight, the force of the weight is magnified to the knee. For example, that ten pounds is really more like 30-50 pounds of extra force. Twenty pounds is more like 100 pounds of excessive force. So imagine wearing a 100-pound backpack, and squatting 250 pounds for repetitions of 12 and 3 sets? Elite Competitive bodybuilders while their body fat is lower may weigh 300 pounds, but may squat 500 pounds or leg press even more. Their sets and repetitions are higher, and they measure their workouts in total volume lifter it tons of weight lifted in a day. Over decades this has an enormous wear and tear effect upon the knee joint resulting in accelerated degenerative knee osteoarthritis.

Dr. Lox an expert in Sports and Regenerative Medicine, has treated athletes of all sports, and frequently encounters weight lifters, and bodybuilders with knee pain. Regenerative Medicine applications under the supervision of a Sports and Regenerative Medicine specialist may halt the progressive nature of knee arthritis or reverse it. This is truly a medical game changer for athletes. Regenerative Medicine incorporates the body’s innate healing capacity to achieve repair.

By definition osteoarthritis is a progressive disorder. Traditional medical strategies such as anti-inflammatory arthritis medications (NSAIDS), cortisone, and even surgery do not halt the degenerative progressive cascade of arthritis. Patients and athletes are increasingly turning to Regenerative Medicine as an alternative treatment strategy to alter this prophecy of progressive knee joint wear. Many patients and athletes do not want a knee replacement surgery, and Regenerative Medicine is a viable treatment strategy to be proactive.

A proactive strategy is much more palatable to athletes than being told to just wait and sooner or later you will get your knee replaced. Every patient is different. Each patient and athlete needs individual assessment for optimal treatment. Consulting a skilled and experienced Sports and Regenerative Medicine Specialist is essential to the best outcome for each patient.



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Avascular Necrosis of the Hip

Avascular Necrosis of the Hip

Avascular Necrosis of the Hip

Avascular Necrosis (AVN) of the hip is the most common presentation of AVN. Avascular necrosis (AVN) also referred to as osteonecrosis occurs when the blood flow to a region of bone is disrupted leading to ischemia or bone cell death (necrosis). Stem cells have been used as therapeutic options in various forms of treatment. The hip may develop AVN on one side, or be present in both hips referred to as bilateral.

The most frequent cause of AVN is trauma. Famous athletes such as Bo Jackson have had their sports career derailed as the result of AVN. This is why alternative treatment measures to help repair or regenerate the bone have spawned interest in stem cells and Regenerative Medicine.

Other than trauma an unknown origin of avascular necrosis is referred to as idiopathic. Following this certain disease states and results of medical treatment can induce or are associated with increased risk of developing AVN. This includes excessive corticosteroids (cortisone), excessive alcohol consumption, radiation therapy, chemotherapy, sickle cell disease, Lupus, Rheumatoid Arthritis and decompression sickness.

AVN may occur in the hip and another joint such as the knee or involve multiple joints. This is typically the result of systemic disease or treatment.

If the hip is severely involved, a rapid joint collapse may occur leading to recommendations for hip replacement surgery. Alternative strategies utilizing the reparative and regenerative capacity of stem cells have involved surgical micro-fracture or core decompression, injections involving stem cell concentrates, growth factors have been explored to avoid hip replacement surgery.

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A Patient from Qatar flies for Qatar for Knee Stem Cells with Expert Dr. Lox

A Patient from Qatar flies for Qatar for Knee Stem Cells with Expert Dr. Lox

A Patient from Qatar flies for Qatar for Knee Stem Cells with Expert Dr. Lox

A patient from Qatar flew to the Tampa Bay, Florida office of Dr. Dennis Lox to evaluate his knee for Regenerative Medicine treatment and stem cell therapy. Dr. Lox a frequent lecturer on national and international Regenerative Medicine topics including Stem Cell Science, Tissue Engineering, Sports Medicine, Knee osteoarthritis and Avascular necrosis (AVN) has patients from around the globe and nation consult him for his expertise.

Patients requesting an evaluation for knee pain is a frequent request seen by Dr. Lox.
Patients question stem cell treatments, the science, alternatives to knee surgery quite often. Patients are often told they will need a total knee replacement surgery, and this often leads them to see Dr. Lox for alternatives.

Knee arthritis or more appropriately termed knee osteoarthritis is one of the most common conditions affecting the aging population. The incidence of total knee and hip replacement surgery is over a million cases in the United States alone. This makes alternative measures such as Regenerative Medicine, Platelet Rich Plasma, and stem cell applications very appealing.

Knee arthritis or degenerative osteoarthritis is more than just the wear and tear of aging. We now know there is a genetic component, trauma induced, and even post-surgical arthritis. Trauma and surgery combined yields often an accelerated progression of degenerative osteoarthritis. All traditional medical models including surgery do not alter the progressive nature of degenerative arthritis. Non-steroidal anti-inflammatory medications, corticosteroids (cortisone), Hyaluronic acid injections, physical therapy, and knee surgery do not alter the progressive nature of knee degenerative osteoarthritis.

It is the hallmark of Regenerative Medicine and Tissue Engineering strategies that revolve around stem cell science that the progressive nature of degenerative arthritis may be halted or reversed. This is not as complicated when compared to advancements in regrowing body parts, 3-D bioprinting organs, or turning mature skin cells back in time to embryonic-like induced pluripotent stem cells (iPS cells).

Yes the field of Regenerative Medicine, stem cell science and Tissue Engineering is quite advanced. Knee pain though common has been studied with regenerative strategies for a long time.

Dr. Dennis Lox treats Sports and Regenerative Medicine problems not just of knees, but a variety of problems from head to toe. Dr. Lox evaluates patients in his Tampa Bay, Florida office, and in Beverly Hills, California.

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Derrick Brooks NFL Hall of Famer Has Wrist Stem Cells With Dr. Lox

Derrick Brooks NFL Hall of Famer Has Wrist Stem Cells With Dr. Lox

Derrick Brooks NFL Hall of Famer Has Wrist Stem Cells With Dr. Lox

Derrick Brooks a former professional football player with the Tampa Bay Bucs and Hall of fame member had wrist stem cells with Dr. Dennis Lox a world recognized Sports and Regenerative Medicine specialist. Brooks a linebacker with the Tampa Bay Bucs was part of the Bucs Super Bowl winning team in 2003.

Dr. Lox has treated numerous athletes with wrist ailments with Regenerative Medicine strategies such as Platelet Rich Plasma (PRP) and stem cell treatments. Not only has Dr. Lox treated professional athletes wrists, he has also treated a concert pianist’s wrist, a high school athlete who later obtained a collegiate scholarship, professional boxers, mixed martial artists, and many patients with wrist degenerative arthritis or osteoarthritis.

Derrick Brooks’s professional football career was relatively free from significant injury. A truly great feat for a professional football player. After his professional football career, he has maintained an active presence in the Tampa Bay community for a variety of endeavors. Brooks played in the National Football League for 14 seasons.

Derrick Brooks began experiencing more frequent wrist complaints after his professional football playing days were over. Attributing it to his aggressive tackling style. Accumulative stress especially in an extreme impact sport such as football, no doubt can lead to early or an accelerated wear and tear of the joints. This accumulative wear over time can result in early degenerative arthritis manifestations of any joint including the wrist.

After hearing another Professional Football player, former Tampa Bay Buccaneer teammate Ian Beckles discuss Dr. Lox, Derrick began more inquiries, and after fully vetting Dr. Lox he consulted Dr. Lox for his wrists. Then after checking with his personal orthopedic surgeon who called Dr. Lox and discussed Derricks care, Derrick green-lighted moving forward with wrist stem cells with Dr. Dennis Lox. Derrick has been doing well after the wrist stem cell procedure for over 2 years, and readily recommends the stem cell treatment and care with Dr. Dennis Lox.

Dr. Dennis Lox has edited two medical textbooks, written eight textbook chapters, authored scientific articles and lectured nationally and internationally on Sports and Regenerative Medicine topics including Sports, Stem Cells, Tissue Engineering, Avascular Necrosis (AVN) and Osteoarthritis. Dr. Lox maintains a practice in Tampa Bay, Florida and Beverly Hills, California.

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