Avascular Necrosis of the Hip

Avascular Necrosis of the Hip

Avascular Necrosis of the Hip

Avascular Necrosis (AVN) of the hip is the most common presentation of AVN. Avascular necrosis (AVN) also referred to as osteonecrosis occurs when the blood flow to a region of bone is disrupted leading to ischemia or bone cell death (necrosis). Stem cells have been used as therapeutic options in various forms of treatment. The hip may develop AVN on one side, or be present in both hips referred to as bilateral.

The most frequent cause of AVN is trauma. Famous athletes such as Bo Jackson have had their sports career derailed as the result of AVN. This is why alternative treatment measures to help repair or regenerate the bone have spawned interest in stem cells and Regenerative Medicine.

Other than trauma an unknown origin of avascular necrosis is referred to as idiopathic. Following this certain disease states and results of medical treatment can induce or are associated with increased risk of developing AVN. This includes excessive corticosteroids (cortisone), excessive alcohol consumption, radiation therapy, chemotherapy, sickle cell disease, Lupus, Rheumatoid Arthritis and decompression sickness.

AVN may occur in the hip and another joint such as the knee or involve multiple joints. This is typically the result of systemic disease or treatment.

If the hip is severely involved, a rapid joint collapse may occur leading to recommendations for hip replacement surgery. Alternative strategies utilizing the reparative and regenerative capacity of stem cells have involved surgical micro-fracture or core decompression, injections involving stem cell concentrates, growth factors have been explored to avoid hip replacement surgery.

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A Patient from Qatar flies for Qatar for Knee Stem Cells with Expert Dr. Lox

A Patient from Qatar flies for Qatar for Knee Stem Cells with Expert Dr. Lox

A Patient from Qatar flies for Qatar for Knee Stem Cells with Expert Dr. Lox

A patient from Qatar flew to the Tampa Bay, Florida office of Dr. Dennis Lox to evaluate his knee for Regenerative Medicine treatment and stem cell therapy. Dr. Lox a frequent lecturer on national and international Regenerative Medicine topics including Stem Cell Science, Tissue Engineering, Sports Medicine, Knee osteoarthritis and Avascular necrosis (AVN) has patients from around the globe and nation consult him for his expertise.

Patients requesting an evaluation for knee pain is a frequent request seen by Dr. Lox.
Patients question stem cell treatments, the science, alternatives to knee surgery quite often. Patients are often told they will need a total knee replacement surgery, and this often leads them to see Dr. Lox for alternatives.

Knee arthritis or more appropriately termed knee osteoarthritis is one of the most common conditions affecting the aging population. The incidence of total knee and hip replacement surgery is over a million cases in the United States alone. This makes alternative measures such as Regenerative Medicine, Platelet Rich Plasma, and stem cell applications very appealing.

Knee arthritis or degenerative osteoarthritis is more than just the wear and tear of aging. We now know there is a genetic component, trauma induced, and even post-surgical arthritis. Trauma and surgery combined yields often an accelerated progression of degenerative osteoarthritis. All traditional medical models including surgery do not alter the progressive nature of degenerative arthritis. Non-steroidal anti-inflammatory medications, corticosteroids (cortisone), Hyaluronic acid injections, physical therapy, and knee surgery do not alter the progressive nature of knee degenerative osteoarthritis.

It is the hallmark of Regenerative Medicine and Tissue Engineering strategies that revolve around stem cell science that the progressive nature of degenerative arthritis may be halted or reversed. This is not as complicated when compared to advancements in regrowing body parts, 3-D bioprinting organs, or turning mature skin cells back in time to embryonic-like induced pluripotent stem cells (iPS cells).

Yes the field of Regenerative Medicine, stem cell science and Tissue Engineering is quite advanced. Knee pain though common has been studied with regenerative strategies for a long time.

Dr. Dennis Lox treats Sports and Regenerative Medicine problems not just of knees, but a variety of problems from head to toe. Dr. Lox evaluates patients in his Tampa Bay, Florida office, and in Beverly Hills, California.

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Derrick Brooks NFL Hall of Famer Has Wrist Stem Cells With Dr. Lox

Derrick Brooks NFL Hall of Famer Has Wrist Stem Cells With Dr. Lox

Derrick Brooks NFL Hall of Famer Has Wrist Stem Cells With Dr. Lox

Derrick Brooks a former professional football player with the Tampa Bay Bucs and Hall of fame member had wrist stem cells with Dr. Dennis Lox a world recognized Sports and Regenerative Medicine specialist. Brooks a linebacker with the Tampa Bay Bucs was part of the Bucs Super Bowl winning team in 2003.

Dr. Lox has treated numerous athletes with wrist ailments with Regenerative Medicine strategies such as Platelet Rich Plasma (PRP) and stem cell treatments. Not only has Dr. Lox treated professional athletes wrists, he has also treated a concert pianist’s wrist, a high school athlete who later obtained a collegiate scholarship, professional boxers, mixed martial artists, and many patients with wrist degenerative arthritis or osteoarthritis.

Derrick Brooks’s professional football career was relatively free from significant injury. A truly great feat for a professional football player. After his professional football career, he has maintained an active presence in the Tampa Bay community for a variety of endeavors. Brooks played in the National Football League for 14 seasons.

Derrick Brooks began experiencing more frequent wrist complaints after his professional football playing days were over. Attributing it to his aggressive tackling style. Accumulative stress especially in an extreme impact sport such as football, no doubt can lead to early or an accelerated wear and tear of the joints. This accumulative wear over time can result in early degenerative arthritis manifestations of any joint including the wrist.

After hearing another Professional Football player, former Tampa Bay Buccaneer teammate Ian Beckles discuss Dr. Lox, Derrick began more inquiries, and after fully vetting Dr. Lox he consulted Dr. Lox for his wrists. Then after checking with his personal orthopedic surgeon who called Dr. Lox and discussed Derricks care, Derrick green-lighted moving forward with wrist stem cells with Dr. Dennis Lox. Derrick has been doing well after the wrist stem cell procedure for over 2 years, and readily recommends the stem cell treatment and care with Dr. Dennis Lox.

Dr. Dennis Lox has edited two medical textbooks, written eight textbook chapters, authored scientific articles and lectured nationally and internationally on Sports and Regenerative Medicine topics including Sports, Stem Cells, Tissue Engineering, Avascular Necrosis (AVN) and Osteoarthritis. Dr. Lox maintains a practice in Tampa Bay, Florida and Beverly Hills, California.

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Dr. Dennis Lox Talks Stem Cells on ABC News with Teen Soccer Player with AVN

Dr. Dennis Lox Talks Stem Cells on ABC News with Teen Soccer Player with AVN

Dr. Dennis Lox Talks Stem Cells on ABC News with Teen Soccer Player Natasha Merangoli with AVN

Dr. Dennis Lox a world recognized expert in Sports and Regenerative Medicine with special expertise in Avascular Necrosis (AVN) and stem cells, is interviewed on ABC’s The Morning Blend with a teen soccer player, Natasha Merangoli with ankle AVN.
The teen, Natasha was first interviewed as a 14 year old diagnosed with avascular necrosis of the navicular bone in her foot. She failed to improve with conservative care, was unable to run or play soccer, and was told her only course of treatment was an ankle fusion. This ankle fusion was unacceptable to Natasha or her family, as she would be unable to return to play soccer or even wear high heels. She treated with Dr. Dennis Lox in 2013, and underwent stem cell therapy for her navicular AVN. She improved and became the leading scorer for her high school team as a freshman. Natasha made the news in her hometown of Orlando, and was featured on Fox 35 News that year 2013. The story was entitled Stem Cells Help Soccer Player Recover.

In the next few years she continued to excel in soccer. Serial MRI’s showed improvement of the necrotic region of bone, attributed to her stem cell treatment for her ankle/navicular Avascular necrosis. By her time Natasha was a senior in high school the last MRI showed complete resolution of the region of necrotic region, and the radiologist read the MRI as normal without evidence of the prior avascular necrosis. Truly a successful outcome with Dr. Lox’s Sports and Regenerative Medicine approach with stem cells.

She obtained a scholarship to college for her outstanding play, and was interviewed on ABC’s Morning Blend in 2017, four years after her initial Televison interview on Fox Orlando 35 with Dr. Dennis Lox, and several former professional football players for the Tampa Bay Buccaneers, NFL Hall of Famer Derrick Brooks and Ian Beckles, were also interviewed. Their was a round table discussion of stem cell therapy and how it impacted each persons lives.

Natasha has since left for college. As a freshman she was faced with doing nothing or ankle fusion surgery for her Avascular Necrosis (AVN), she and her family opted to find Dr. Dennis Lox and the rest is history.

Posted in Ankle Pain, Sports Medicine, Stem Cell Therapy | Leave a comment

6 year a 1 year after Knee Stem Cells with Expert Dr. Lox Doing Great

86 year a 1 year after Knee Stem Cells with Expert Dr. Lox Doing Great

86 year a 1 year after Knee Stem Cells with Expert Dr. Lox Doing Great

6 year a 1 year after Knee Stem Cells with Expert Dr. Lox Doing Great

A year after having knee stems with world renown stem cells expert Dr. Dennis Lox, an 86 year old woman states she is doing great. Her initial complaints to Dr. Dennis Lox were pain loss of range of motion, and difficulty walking for prolonged periods. These are normal complaints for patients in their 70’s and beyond. Frequently patients with advance age who have significant degenerative findings are happy with more functional lives. Less pain, more mobility and doing activities of daily living.

Keeping this patient population functional in the home, out of nursing homes or assisted living facilities is a goal for many. As some present with more advanced arthritis, regenerative capacity with stem cells may occur but the arthritis may be so advanced that functional goals are realistic goals. These patients rarely ask to run marathoners as do very active 40-60 year old patients just becoming aware they have knee osteoarthritis. These patients want to be 100% often and are only satisfied if they return to high levels of sport regardless of what degree of knee arthritis they have.

This patient was a motivated patient she lost 38 pounds, returned to walking normally without a limp after knee stem cells with Dr. Lox. She also was noted to now have full knee range of motion, without pain to palpation. Very positive signs of successful treatment after knee stem cells.

Knee osteoarthritis presents at many ages. In an 86 year old year old, the level of arthritis may be moderate or severe enough that total knee replacement has been recommended.

Often patients present to Dr. Lox for alternatives to knee joint replacement surgery.
Stem cells have been seen as a viable treatment alternative in some patients with advanced knee arthritis who desire to avoid knee replacement surgery.

The degree of knee arthritis, overall health, weight, and other joint problems may impact treatment reccomendations. Dr. Lox is patient specific in his approach, as no two patients are alike. Therefore specific instructions are tailored for that patients needs, to achieve the best optimal results.

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Vietnamese Patient with Hip Arthritis Opts for Stem cells with Dr. Lox

Vietnamese Patient with Hip Arthritis Opts for Stem cells with Dr. Lox

Vietnamese Patient with Hip Arthritis Opts for Stem cells with Dr. Lox

A patient from Vietnam with degenerative osteoarthritis, or commonly known as wear and tear arthritis consulted Dennis M. Lox M.D. for stem cell therapy of her hip. She had tried prescription anti-inflammatory medications and cortisone injections to no avail. Her orthopedic surgeon recommended a hip replacement surgery. She had a friend who developed a severe infection after a knee replacement and was reluctant to have hip replacement surgery. Another friend had stem cell therapy with Dr. Lox and was pleased with the results.

She consulted with Dr. Lox in his Tampa Bay, Florida office. Dr. Lox also practices in Beverly Hills, California. After hearing the basic science of stem cells and listening to her options she decided to proceed with hip stem cell therapy with Dr. Lox. She was surprised at how simple it was and admitted she was nervous before hand. Dr. Lox notes that it is not uncommon that patients are nervous before stem cell therapy. Fear of the unknown is frequently cited. It is always the same afterward patients comment on how simple the procedure was that it was not worth being nervous over.

Hip and knee arthritis is a very frequent complaint as women age. The number of hip and knee replacement surgeries in the United States alone is in the millions. More and more patients are looking for alternatives to hip and knee replacement surgery. Stem cell therapy may be a viable option for some of these patients.

Degenerative hip and knee arthritis may occur as we age, but it is not just simply a wear and tear disorder. It is frequently more complex. Some times the pain is sudden, yet the x-rays may be significantly advanced. This can be viewed as silent degeneration of the joint. It may also be of slow onset with aches and pains over years or even decades.

Joint arthritis may also occur after trauma. Post-traumatic arthritis can occur even in patients in their twenties if trauma was significant earlier in life. Abnormal joint wear can occur with alignment derangements such as leg length discrepancy, knock knees or bowed legs. The most prevalent cause for excessive wear is being overweight. The typical American gains 10 pounds per decade. 20-50 pounds of extra weight will cause considerable excessive load on the hips, knees and ankles over time. It is not atypical that arthritis is seen in multiple joints as a result of this.

Trauma accelerates arthritis of the joints as well as prior surgery. Patients may have a combination of many of these factors. Lastly, there is a genetic predisposition to the development of joint arthritis. Fortunately, the field of Regenerative Medicine and stem cell therapy is blossoming and future prospects of earlier treatment and new developments should be bright.

If you’re in pain or had an injury and are looking for an alternative to surgery, in the United States, Canada or another country, contact us immediately at one of our locations. Our Main Medical Center located in Tampa Bay, Florida (727) 462-5582 or at Beverly Hills, California (310) 975-7033. www.drlox.com | info@drlox.com

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A California Golfer with Wrist Pain has Stem Cell Treatment with Dr. Lox

A California Golfer with Wrist Pain has Stem Cell Treatment with Dr. Lox

A California Golfer with Wrist Pain has Stem Cell Treatment with Dr. Lox

A golfer with a five-year history of left wrist pain underwent wrist stem cell therapy with Dr. Dennis Lox at his Beverly Hills, California office. The golfer is not sure exactly of an acute injury, but his wrist pain gradually progressed in his dominant hand over time. This affected not only quality of life issues, but his all important golf game. He elected to undergo wrist stem cell treatment with Dr. Lox a world renown stem cell expert. Dr. Lox has treated many different athletes from a wide spectrum of sports with wrist ailments including professional athletes.

This patient had an MRI of his wrist which revealed a tear of the wrist cartilage known as the triangular fibrocartilaginous complex or more commonly referred to as a tear of the TFCC.

The TFCC is in the center of the wrist and connects to bones in the wrist, and serves also to stabilize the wrist with certain movements. Dr. Lox has treated many athletes with TFCC tears with stem cell therapy to their wrists.

Stem cells are sophisticated repair cells capable of reducing pain that causes inflammation and invoking a repair response to injured tissues. Our bodies lack a substantial quantity of stem cells in our joints to repair ourselves this we can break down after injury and ultimately develop arthritis. Stem cell treatments serve as a way to help our bodies heal themselves.

Dr. Lox has been treating athletes and non-athletes with a wide variety of musculoskeletal and orthopedic problems for over 25 years. Dr. Lox was at the forefront of stem cell therapy in the United States, and frequently lectures to physicians, stem cell researchers and university professors from major institutions, including some of the most influential and world renown stem cell researchers in the world. Dr. Lox has lectured with two such professors who have been featured on 60 minutes for their ground breaking stem cell and Regenerative Medicine research.

Dennis Lox M.D. maintains an active Sports and Regenerative Medicine practice in Beverly Hills, California, and the Tampa Bay, Florida area. Patients from all over the United States and around the globe have treated with Dr. Lox.

If you’re in pain or had an injury and are looking for an alternative to surgery, in the United States, Canada or another country, contact us immediately at one of our locations. Our Main Medical Center located in Tampa Bay, Florida (727) 462-5582 or at Beverly Hills, California (310) 975-7033. www.drlox.com | info@drlox.com

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A Professional Boxer with Hand Injury Consults Dr. Lox for Stem Cells

A Professional Boxer with Hand Injury Consults Dr. Lox for Stem Cells

A Professional Boxer with Hand Injury Consults Dr. Lox for Stem Cells

An undefeated professional boxer visited Dr. Lox for hand stem cell therapy, as his hand injury failed to improve after surgery. Not only was boxing his way to make a living it was his passion. Being undefeated is not easy. Trying to box with a hand injury is very difficult. This boxer had trouble making a fist and punching without pain. He had a tendon and bone injury of his hand. Dr. Lox has treated many professional athletes with a variety of sports and orthopedic problems with stem cell therapy. All have returned to professional sports for varied periods, even those who did not improve with surgery. This list includes professional football and baseball players. Even professional ballerinas and pianists have been treated by Dr. Lox with stem cell therapy.

Boxers like martial artists strike with their hands. The inability to make a fist without pain or pain upon punching is detrimental to success in that sport. An undefeated professional boxer risks his ranking, undefeated status and monetary compensation by competing with an injured hand. For these reasons, this boxer sought the care of Dr. Lox for hand stem cell therapy. The boxer was referred by two of Dr. Lox’s patients who were athletes and did well with stem cell therapy. There are many types of injuries that occur in the tissues of the hand that may not resolve with surgery. Dr. Lox has treated many of these conditions. It is important to be evaluated by an expert such as Dr. Lox to determine the best course of action. No two patients are alike. There is no cookie cutter template for each patient. A personalized approach tailored for each patients condition, needs, and goals should be evaluated to achieve the best results. Dr. Lox uses this personalized medicine approach and has for numerous years to achieve the best results.

All patients, not just professional athletes should be treated this way. It is important to evaluate a potential physician who states they are going to perform stem cell therapy for their experience and training. This is true of all areas of medicine. One would not want to have heart surgery by a doctor who took an online course. Unfortunately, there are individuals who make claims without the experience in stem cell therapy. Professional athletes are generally referred by those in the know or other patients. Too much is at risk to trust your career to an inexperienced physician. There is nothing wrong with asking questions. Dr. Lox has lectured to university professors. Having your questions answered and having trust in your doctor is important.

Stem cell therapy may be a very good choice for certain patients. The knowledge of when and how to treat, especially professional athletes is important.

If you’re in pain or had an injury and are looking for an alternative to surgery, in the United States, Canada or another country, contact us immediately at one of our locations. Our Main Medical Center located in Tampa Bay, Florida (727) 462-5582 or at Beverly Hills, California (310) 975-7033. www.drlox.com | info@drlox.com

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Tampa Bay’s Morning Blend


Dennis M. Lox M.D. is a world renown expert in the use of stem cells in Sports and Regenerative Medicine. Dr. Lox has treated professional athletes from all types of sports, weekend warriors, and patients who just want a better quality of life. Dr. Lox is extremely thorough, and the knowledge of an expert such as Dr. Lox is invaluable, and this is why patients from around the world have traveled to treat with Dr. Lox for stem cell therapy at his Tampa Bay and Beverly Hills, California office.

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Patient from New York with Hip AVN states he is 100% better

A Patient from New York with Hip AVN states he is 100% after Stem Cells with Dr. Lox

A Patient from New York with Hip AVN states he is 100% better.

A patient with hip avascular necrosis (AVN) who lives in New York, flew to see Dennis M. Lox M.D. an expert in stem cell therapy in his Tampa Bay, Florida clinic. Dr. Lox also maintains an active practice in Beverly Hills, California. The patient elected to proceed with stem cell therapy for his hip AVN, after Dr. Lox explained the process, gave him a better understanding of avascular necrosis (AVN), and what to expect.

2 years later he reported to Dr. Lox that he was 100% better. Not every patient will report such success, however when they do it is extremely rewarding. Patients view success on different criteria. Some are not the same as the doctor’s viewpoint. Doctor’s tend to look at clinical signs or radiographic evidence of change. However, when treating thousands of stem cell patients as an experienced expert such as Dr. Lox has done, success needs to as take into account a patients goals and expectations. Sometimes these two goals and expectations are not realistic, especially when dealing with a condition such as avascular necrosis (AVN) and stem cell treatment. An experienced expert physician like Dr. Dennis Lox will discuss these issues before hand with all patients. AVN patients need special counseling on goals and expectations due to variabilities in age, the extent of AVN involvement, whether there are multiple joints involved, and if a return to sport is an issue.

Avascular necrosis occurs when blood flow becomes impaired to a region of bone resulting in bone cell death from the lack of blood flow. This is termed necrosis. The necrotic bone may be a small region or large. The necrosis may occur in multiple joints. The hip joint is the most commonly affected joint with AVN, and therefore stem cells for hips are the most common site treated. AVN of both hips is the most common presentation of multiple joint involvements, yet it may also present in a hip and a knee. Various other patterns occur. Dr. Lox has seen practically all types. Both hips, both knees, and both ankles were seen in one of Dr. Lox’s patients. The shoulder is the second most common joint affected with avascular necrosis. AVN has also been referred to by other names such as osteonecrosis, ischemic necrosis, aseptic necrosis, and bone infarction. All the names allude to bone necrosis.

Preceding trauma is the most frequent presentation of avascular necrosis. There are times where the trauma is not thought of as that significant as pain is part of the trauma. When pain persists beyond a reasonable time period or is out of proportion to the degree of injury, the diagnosis of AVN or osteonecrosis should be considered. MRI changes are seen early before x-ray images reflect any evidence of AVN.

Idiopathic or osteonecrosis (AVN) of unknown etiology is second to trauma in underlying causation. Sometimes the AVN is not caused by a specific process but has associated risk factors. These include excessive corticosteroid (cortisone) and alcohol use. It is not clear why some individuals who have excessive cortisone or alcohol intake develop osteonecrosis or AVN and others do not. There are many other associated risk factors involved with AVN.

Due to the complexity of AVN and the management with stem cell therapy, it is important to consult with an expert such as Dr. Dennis Lox. Athletes, in particular, have unique needs and Dr. Lox has treated many athletes with AVN, including high school athletes who were told they could not return to their chosen sport, and eventually did even obtaining athletic scholarships to college after stem cell therapy with Dr. Lox.

Dennis M. Lox M.D. specializes in Sports and Regenerative Medicine with stem cell therapy. Dr. Lox may be contacted at his office in the Tampa Bay, Florida area as well as Beverly Hills, California.

If you’re in pain or had an injury and are looking for an alternative to surgery, in the United States, Canada or another country, contact us immediately at one of our locations. Our Main Medical Center located in Tampa Bay, Florida (727) 462-5582 or at Beverly Hills, California (310) 975-7033. www.drlox.com | info@drlox.com

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